From Boston and points north and east, I-90 will take travelers past Worcester in the southern part of the region. Route 2 traverses westward from Boston in the northern part of the region, passing Fitchburg, Leominster, and Gardner.
From New Hampshire, Vermont, and points north, take I-91 South to Route 2 East or Massachusetts Turnpike East.
From upstate New York and points west, I-90 travels through Massachusetts and into Worcester before continuing into Boston.
From Connecticut, Rhode Island, New York City, and points south and west, I-395 travels north from I-95 into Worcester. To continue further north, travelers can pick up I-190, which ends at Route 2.